The effect of excipients on pharmacokinetic parameters of parenteral drugs
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Predicting Protein Binding of Drugs Using Abraham Parameters: Effect of Ionization
Background and purpose: Protein binding (PB) is an important pharmacokinetic parameter in drug discovery and development. In past years Abraham parameters were used to predict some physicochemical and pharmacokinetic properties of drugs. But in these cases, the ionization of drugs in blood pH (7.4) was ignored. Recently, Abraham parameters of chemical compounds in ionized form are proposed. Als...
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